The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens? Written from the industry perspective and based on many years of experience, this book offers: - Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs - Guidance for exploration and modification of these programs to enhance the understanding of key principles - Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature - A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling. Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.
This comprehensive reference guide describes more than 130 alphabetically arranged drugs of abuse, including both pharmaceutical and natural products. The book begins with a discussion of federal drug scheduling and drug categories. Individual entries for particular substances of abuse follow. Drug descriptions include: correct pronunciation, nicknames or street names, legal status, historical and present uses and misuses, abuse factors, interactions with other drugs, and findings of cancer risks and birth defects. Scientific information is presented in a clear, simple manner designed for students and general readers alike. In addition to the A-Z descriptions, Miller provides an explanation of general drug types, such as stimulants and hallucinogens, as well as the aspects of drug abuse, including tolerance and withdrawal. A list of print and electronic sources is also included for readers seeking further information.
The Side Effects of Drugs Annual was first published in 1977. It has been published continuously since then, as a yearly update to the encyclopaedic volume Meyler's Side Effects of Drugs. Each new Annual provides clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists have contributed to the Annuals by selecting from each year's publications all that is truly new and informative, by critically interpreting it, and by pointing out whatever is misleading. The use of the book is enhanced by separate indexes, allowing the reader to enter the text via the drug name, adverse effect, or drug interaction. Special features of the Annuals are the Side Effects of Drugs Essay, usually written by a guest author, and the special reviews: short articles, within the different chapters, that give extra attention to topics of current interest. The Essay in Annual 27 is entitled 'The General Practice Research Database' (by Dr. H. Jick) and there is a Historical Essay entitled 'Louis Lewin - Meyler's Predecessor' (by Dr. J.K. Aronson). The special reviews in this volume include, among others: The effects of NSAIDs on blood pressure Risks of inhaled corticosteroids in children Leukotriene receptor antagonists and Churg-Strauss syndrome Amiodarone and thyroid disease Surveillance of adverse events following immunization Smallpox vaccination Safety aspects of folic acid Inhibitors of topoisomerase I and topoisomerase II Liver damage from kava kava
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