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Recent years have seen enormous advances in the field of protein and peptide engineering and a greater understanding in the way in which biological response modifiers function in the body. It is now possible through the use of recombinant DNA techniques, or by solid phase protein synthesis, to produce significant quantities of a wide variety of regulatory agents that are therapeutically applicable. The list of these response modifiers expands almost daily to include interferons, macrophage activation factors, neuropeptides and agents that may have potential in cardiovascular disease, inflammation, contraception etc. Prospects to use some of these materials in medicine have reached the stage where products have either been approved by regulatory authorities or are the subject of applications as investigatory drugs or as new therapeutic agents. In some uses the pertinent agent will be administered on an acute basis in the form of a simple injection, as, for example, the use of a tissue plasminogen activator for the treatment of coronary infarct. In other cases regulatory proteins and peptides are indicated for chronic therapy and here they will need to be administered by an appropriate delivery system. Unfortunately, the research on delivery systems for peptides and proteins has not kept pace with the rapid progress in biotechnology and, consequently, there are presently few systems that are entirely appropriate for the administration of macromolecular drugs according to complex dosage regimens, (eg intermittent and pulsed therapy). Furthermore essential pharmacokinetic and pharmacodynamic data may be missing.
The library. A place usually thought of in the context of browsing for books with the help of the shy librarian. This new comic strip blows that image out of the water. Come join us and see that the library world is filled with absolute sarcasm, irreverence, controversy, shocking behavior, a dark side, and all of it is completely hilarious. Dewey Decimal on Drugs will leave you laughing on the floor at the rebellious antics of the staff as they take on patrons and management alike with equal indifference. The humor in this book is never ever quiet and one can never say shhh to the laugh out loud honesty.
This book details all of the relevant information on the fragmentation of drugs and pesticides. It extends this information by the interpretation of series of mass spectra in available mass spectral library collections for liquid chromatography - tandem mass spectrometry (LC-MS-MS). The information provided indicates important fragmentation pathways in the various chemical compound classes. Whenever available or useful, fragmentation in both positive-ion and negative-ion mode is discussed and compared. This is important since no complete databases about the fragmentation of these substances are available, and the information on to interpreting unknown fragments is scattered. Thus, this book will provide important information on how to interpret spectra so that fragments can be correctly identified that are not contained in a database.
Important classes of compounds discussed include pesticides and related compounds as well as drugs for cardiovascular diseases and hypertension, psychotropic or psychoactive drugs, drugs related to digestion and the gastrointestinal tract, antimicrobial compounds, and other classes of drugs, such as steroids, drugs of abuse.
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