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The endothelium, the cell layer that forms the inner lining of blood vessels, is a spatially distributed system that extends to all reaches of the human body. Today, clinical and basic research demonstrates that the endothelium plays a crucial role in mediating homeostasis and is involved in virtually every disease, either as a primary determinant of pathophysiology or as a victim of collateral damage. Indeed, the endothelium has remarkable, though largely untapped, diagnostic and therapeutic potential. This volume endeavors to bridge the bench-to-bedside gap in endothelial biomedicine, with the goal of advancing research and development and improving human health. The book is the first to systematically integrate knowledge about the endothelium from different organ-specific disciplines, including neurology, pulmonary, cardiology, gastroenterology, rheumatology, infectious disease, hematology-oncology, nephrology, and dermatology. Moreover, it is unique in its interdisciplinary approach, drawing on expertise from such diverse fields as evolutionary biology, comparative biology, molecular and cell biology, mathematical modeling and complexity theory, translational research, and clinical medicine.
Leading practitioners detail revolutionary new spectrometric techniques for the identification and covalent structural characterization of macromolecules, proteins, glycoconjugates, and nucleic acids. Based on the Fourth International Symposium on Mass Spectrometry in the Health and Life Sciences held in San Francisco in 1998, this invaluable book contains tested strategies for solving many significant biomedical research problems. The techniques use mass spectrometry, automated computer processing of spectral information, and gene, protein, and EST databases for genomic and proteomic correlations. Mass Spectrometry in Biology and Medicine offers a unique opportunity to explore and apply these new techniques of mass spectrometry that are revolutionizing the identification and structural characterization of proteins, carbohydrates, and nucleic acids.
The first book of its kind, Forensic Medicine in Western Society: A History draws on the most recent developments in the historiography, to provide an overview of the history of forensic medicine in the West from the medieval period to the present day. Taking an international, comparative perspective on the changing nature of the relationship between medicine, law and society, it examines the growth of medico-legal ideas, institutions and practices in Britain, Europe (principally France, Italy and Germany) and the United States.
Following a thematic structure within a broad chronological framework, the book focuses on practitioners, the development of notions of 'expertise' and the rise of the expert, the main areas of the criminal law to which forensic medicine contributed, medical attitudes towards the victims and perpetrators of crime, and the wider influences such attitudes had. It thus develops an understanding of how medicine has played an active part in shaping legal, political and social change.
Including case studies which provide a narrative context to tie forensic medicine to the societies in which it was practiced, and a further reading section at the end of each chapter, Katherine D. Watson creates a vivid portrait of a topic of relevance to social historians and students of the history of medicine, law and crime.
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